[HTML][HTML] Transforming growth factor-β stimulates the production of osteoprotegerin/osteoclastogenesis inhibitory factor by bone marrow stromal cells
H Takai, M Kanematsu, K Yano, E Tsuda… - Journal of Biological …, 1998 - ASBMB
Osteoprotegerin (OPG)/osteoclastogenesis inhibitory factor (OCIF) is a recently identified
cytokine that belongs to the tumor necrosis factor receptor superfamily and regulates bone
mass by inhibiting osteoclastic bone resorption. The present study was undertaken to
determine whether OPG/OCIF is produced in bone microenvironment and how the
expression is regulated. A transcript for OPG/OCIF at 3.1 kilobases was detected in bone
marrow stromal cells (ST2 and MC3T3-G2/PA6) as well as in osteoblastic cells (MC3T3-E1) …
cytokine that belongs to the tumor necrosis factor receptor superfamily and regulates bone
mass by inhibiting osteoclastic bone resorption. The present study was undertaken to
determine whether OPG/OCIF is produced in bone microenvironment and how the
expression is regulated. A transcript for OPG/OCIF at 3.1 kilobases was detected in bone
marrow stromal cells (ST2 and MC3T3-G2/PA6) as well as in osteoblastic cells (MC3T3-E1) …